منابع مشابه
Dmd059204 1627..1639
The contribution of drug metabolites to the pharmacologic and toxicologic activity of a drug can be important; however, for a variety of reasons metabolites can frequently be difficult to synthesize. To meet the need of having samples of drug metabolites for further study, we have developed biosynthetic methods coupled with quantitative NMR spectroscopy (qNMR) to generate solutions of metabolit...
متن کاملOp-brai140080 1627..1642
1 Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, and Centre for Neuroscience and Regeneration Research, Veterans Affairs Medical Centre, West Haven, CT 06516, USA 2 Department of Neurology, University Medical Centre Maastricht, Maastricht, The Netherlands 3 Department of Clinical Genetics, University Medical Centre Maastricht, Maastricht, The Netherlands 4 Neu...
متن کاملC2an36787d 1619..1627
Detection elements play a key role in analyte recognition in biosensors. Therefore, detection elements with high analyte specificity and binding strength are required. While antibodies (Abs) have been increasingly used as detection elements in biosensors, a key challenge remains – the immobilization on the biosensor surface. This minireview highlights recent approaches to immobilize and study A...
متن کاملDev103614 1627..1637
Thymic involution is central to the decline in immune system function that occurs with age. By regenerating the thymus, it may therefore be possible to improve the ability of the aged immune system to respond to novel antigens.Recently, diminishedexpressionof the thymic epithelial cell (TEC)-specific transcription factor Forkhead box N1 (FOXN1) has been implicated as a component of themechanism...
متن کاملDev120543 1616..1627
Neural progenitor cells (NPCs) have distinct proliferation capacities at different stages of brain development. Lin28 is an RNA-binding protein with two homologs in mice: Lin28a and Lin28b. Here we show that Lin28a/b are enriched in early NPCs and their expression declines during neural differentiation. Lin28a single-knockout mice show reduced NPC proliferation, enhanced cell cycle exit and a s...
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ژورنال
عنوان ژورنال: The Boston Medical and Surgical Journal
سال: 1919
ISSN: 0096-6762,1533-4406
DOI: 10.1056/nejm191904031801404